Cholesterol level sperm production

Cholesterol is essential for mammalian cell functions and integrity. It is an important structural component maintaining the permeability and fluidity of the cell membrane. The balance between synthesis and catabolism of cholesterol should be tightly regulated to ensure normal cellular processes. Male reproductive function has been demonstrated to be dependent on cholesterol homeostasis. Here we review data highlighting the impacts of cholesterol homeostasis on male fertility and the molecular mechanisms implicated through the signaling pathways of some nuclear receptors. Infertility is a major public health issue defined by the World Health Organization as the inability of a couple to conceive a child after 1 year of unprotected regular sex.
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High Cholesterol Levels May Make It Harder to Get Pregnant

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Low Sperm Count May Signal Serious Health Risks for Men

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Cholesterol: A Gatekeeper of Male Fertility?

Cholesterol plays an essential role in ensuring that our organism works correctly. Its impact on the heart is still given priority in terms of analysis because of the elevated impact and frequency of diseases of this kind. Whilst all the other areas of influence have been analysed to a much lesser degree, in some cases such as infertility , the effects of this essential component are now starting to come to light. What is the importance of cholesterol in fertility?
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We aimed to explore the associations between different lipid profiles and semen quality in a large-scale general male population. Sperm concentration, total sperm motility, progressive motility, and normal sperm morphology of total participants were recorded. The association of these semen parameters with the triglyceride, total cholesterol, high-density lipoprotein, low-density lipoprotein, and very low-density lipoprotein of serum lipid profiles was analyzed.
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